Secondary Prevention of Small Subcortical Strokes (SPS3)

SPS3 is a study for persons who have experienced a small subcortical stroke also known as a lacunar stroke. The main goal of this study is to learn more about preventing another stroke from happening to people who have already had a subcortical stroke. We also want to learn how to prevent problems with thinking and memory decline that may happen after a stroke. This study is testing if taking both aspirin and clopidogrel will be more effective in preventing another stroke than just aspirin alone. As well, this study is seeking information about the best level of blood pressure control after a stroke.

The National Institutes of Health (NIH) in Washington, D.C., is sponsoring this study.

SPS3 is taking place in over 60 different medical centers around the United States, Canada, Latin America, and Europe. In order to answer these important questions, we need 3000 people to participate in this study. The goal of the study is to include at least 20% Hispanics as this type of stroke is thought to be more common in Hispanics than other populations.

SPS3 in the Media

It was Halloween night, Oct. 31, 2003. Amelia Talamantes, 44, was alone in her home, getting ready to work the graveyard shift at the Holiday Inn. Her eldest daughter, Esperanza, had taken the children trick-or-treating. Talamantes was just about to step out into the cool, dark evening when suddenly, in silence and without warning, something attacked her.

The next morning, Talamantes found herself in the hospital. Her mouth was contorted and her speech slurred. Numbness enveloped the fingers in her left hand, continued up her arm and peaked with a sharp ache in her left shoulder. An MRI indicated a small perforation in her brain.

"You had a stroke," Talamantes recalls the doctor telling her, as he pointed to the tiny, dark spot in her brain displayed on the MRI. "I didn't believe it," said the single mother of four. "I was too young to have a stroke," she said, wiping away tears. "All I could do at that moment was think about my children." ....Read More here


Want to Learn More about SPS3?

Click Here to Visit the NINDS Clinical Trials Site

Sponsored by National Institute Health - NINDS: 2 U01 NS38529-04A1

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